25 November 2008
26 November 2008
| E | Villarreal | 20:45 | Man. United | |
| E | AaB | 20:45 | Celtic | |
| F | Bayern | 20:45 | Steaua | |
| F | Fiorentina | 20:45 | Lyon | |
| G | Fenerbahçe | 20:45 | Porto | |
| G | Arsenal | 20:45 | Dynamo Kyiv | |
| H | Zenit | 18:30 | Juventus | |
| H | BATE | 20:45 | Real Madrid |
26 November 2008
| A | Bordeaux | 20:45 | Chelsea | |
| A | CFR Cluj | 20:45 | Roma | |
| B | Internazionale | 20:45 | Panathinaikos | |
| B | Anorthosis | 20:45 | Bremen | |
| C | Shakhtar | 20:45 | Basel | |
| C | Sporting | 20:45 | Barcelona | |
| D | Atlético | 20:45 | PSV | |
| D | Liverpool | 20:45 | Marseille |
